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Publications
The Fruits of Our Labor
paper
Papers
2024
51. Junguang Wu, Xuan Bai, Liang Yan, Didar Baimanov, Yalin Cong, Peiyu Quan, Rui Cai, Yong Guan, Wei Bu, Binhua Lin, Jing Wang, Shengtao Yu, Shijiao Li, Yu Chong, Yang Li, Guoqing Hu, Yuliang Zhao, Chunying Chen* ,Liming Wang* Selective regulation of macrophage lipid metabolism via nanomaterials’ surface chemistry Nat Commun 15, 8349 (2024), doi: https://doi.org/10.1038/s41467-024-52609-7
50. Didar Baimanov#, Su Li#, Xuejiao J. Gao, Rui Cai, Ke Liu, Junjie Li, Yuchen Liu, Yalin Cong, Xiaoyu Wang, Fen Liu, Qi Li, Guofang Zhang, Hui Wei, Jian Wang, Chunying Chen, Xingfa Gao*, Yang Li* and Liming Wang*, A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy. Chemical Science, 2024, doi: 10.1039/d4sc01690d
52. Jingyi Li, Yaqi Yang, Guofang Zhang, Jianfei Sun, Yang Li, Bing Song*,
Therapeutic advances of magnetic nanomaterials in chronic wound healing Nano Today, Volume 60,2025,102554， https://doi.org/10.1016/j.nantod.2024.102554
49. Yingnan Liu, Guofang Zhang, Qi Li, Jiaxin Chen, Wenhe Luo, Xuejin Li, Xiaoman Suo, Su Li, Yaqing Xu, Tinghao Liu, Feng Yuan, Fangfang Liu, Yanqiao Zeng, Yingze Wang, Yang Li*, Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy, Chemical Engineering Journal, 2024, doi: https://doi.org/10.1016/j.cej.2024.151437
48. Zhong-Da Li, Fangfang Liu, Yanqiao Zeng, Yingnan Liu, Wenhe Luo, Feng Yuan, Su Li, Qi Li, Jiaxin Chen, Mayumi Fujita, Guofang Zhang, Yang Li*, EGCG suppresses PD-1 expression of T cells via inhibiting NF-κB phosphorylation and nuclear translocation International Immunopharmacology, 2024, doi : https://doi.org/10.1016/j.intimp.2024.112069
47. Guofang Zhang, Xiaofeng Wang, Guocheng Wang, Xiaoman Suo, Yu Qiu, Rong-Hua Luo, Yingnan Liu, Qi Li, Wenhe Luo, Zhenzhen Shi, Fangfang Liu, Zhongda Li, Jing Qu, Liang Li, Neus G. Bastús, Martin Himly, Liming Wang, Feng-Liang Liu, Yong-Tang Zheng, Victor Puntes, Yang Li*. Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2. Nano Today. 2024,102183. doi : https://doi.org/10.1016/j.nantod.2024.102183
2023
46. Ben Wu, Guofang Zhang, Jiawen Ji, Rong-Hua Luo, Junkang Chen, Feng-Liang Liu, Emerson Coy, Sergio E. Moya, Qi Li, Xiaoman Suo, Xinyue Chen, Yong-Tang Zheng, Yang Li*, Guocheng Wang*. ZIF-67-Derived Antivirus Cobalt Hydroxide LDH Nanosheets Produced through High-Concentration Cobalt Ion-Assisted Hydration. Advanced Functional Materials. 2023, 2312941.doi : https://doi.org/10.1002/adfm.202312941
45. Mengyu Guo, Muya Xiong, Jinying Peng , Tong Guan, Haixia Su, Yanyi Huang , Cai-Guang Yang, Yang Li , Diana Boraschi, Thanigaimalai Pillaiyar, Guanbo Wang, Chengqi Yi , Yechun Xu , Chunying Chen . Multi-omics for COVID-19: driving development of therapeutics and vaccines. Natl Sci Rev. 2023 May 30;10(9):nwad161. doi: 10.1093/nsr/nwad161.
44. Wenhe Luo, Yanqiao Zeng, Qingle Song, Yu Wang, Feng Yuan, Qi Li, Yingnan Liu, Su Li, Nahar Jannatun, Guofang Zhang, Yang Li*. Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia-Responsive Nanogels. Adv Healthc Mater. 2023 doi: 10.1002/adhm.202302865.
43. Muhammad Ovais, Guofang Zhang, Yang Li* . Tailoring multivalent nanomedicines for monkeypox. Nano Today, 2023, Online. doi: doi.org/10.1016/j.nantod.2023.101971
42. Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang*, and Guocheng Wang*. Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly. ACS Biomaterials Science & Engineering, 2023, Online. doi: doi.org/10.1021/acsbiomaterials.3c00090
41. Nahar Jannatun, Yuqian Zhang, Ben Wu, Qingle Song, Guoli Cao, Wenhe Luo, Feng Yuan, Qi Li, Yanqiao Zeng, Guofang Zhang*, Guocheng Wang*, Yang Li*. Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-Oncotherapy. ACS Applied Nano Materials, 2023, 6(6), 4379–4389. doi: doi.org/10.1021/acsanm.2c05472
40. Wenjie Yang, Yang Li, Diana Boraschi*. Association between Microorganisms and Microplastics: How Does It Change the Host–Pathogen Interaction and Subsequent Immune Response?. International Journal of Molecular Sciences, 2023, 24(4),4065. doi: doi.org/10.3390/ijms24044065
2022
39. Wenjie Yang, Nahar Jannatun, Yanqiao Zeng, Tinghao Liu, Guofang Zhang, Chunying Chen*, Yang Li*. Impacts of microplastics on immunity. Frontiers in Toxicology, 2022, 4,956885. doi: doi.org/10.3389/ftox.2022.956885
38. Della Camera, Giacomo, Tinghao Liu, Wenjie Yang, Yang Li, Victor F. Puntes, Sabrina Gioria, Paola Italiani, , Diana Boraschi*. Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles. International Journal of Molecular Sciences, 2022, 23(23),14655. doi: doi.org/10.3390/ijms232314655
37. Guofang Zhang, Wenhe Luo, Wenjie Yang,Su Li, Dongjie Li, Yanqiao Zeng, Yang Li*. The importance of the IL-1 family of cytokines in nanoimmunosafety and nanotoxicology. WIREs Nanomedicine and Nanobiotechnology, 2022, 14(6),e1850. doi: doi.org/10.1002/wnan.1850
36. Xuejin Li, Dongjie Li, Guofang Zhang*, Yanqiao Zeng, Nancy A Monteiro-Riviere, Yan-Zhong Chang* and Yang Li*. Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes. Toxicology Letters, 2022, 369,34-42. doi: doi.org/10.1016/j.toxlet.2022.08.009
35. Guofang Zhang, Yalin Cong, Feng-Liang Liu, Jiufeng Sun, Jiantian Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yu-Feng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yan-Zhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng*, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang* and Yang Li*. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nature Nanotechnoloy, 2022, 17 (9), 993-1003. doi: doi.org/10.1038/s41565-022-01177-2
34. Guofang Zhang, Guoli Cao, Rong-Hua Luo, Qingle Song, Yanqiao Zeng, Ke Liu, Jing Qu, Xian Lin, Feng-Liang Liu, Guocheng Wang, Hongchang Li, Liang Li, Yong-Tang Zheng, Diana Boraschi, Lidong Wu*, Yan-Zhong Chang* and Yang Li*. Microplastics interact with SARS-CoV-2 and facilitate host cell infection. Environmental Science: Nano, 2022, 9,2653-2664. doi: doi.org/10.1039/D2EN00019A
33. Yuange Chen, Longling Ouyang, Na Liu, Fang Li, Peiyi Li, Mengmeng Sun, Haiyang Qin, Yang Li, Xueping Xiang, Lidong Wu*. pH-responsive magnetic artificial melanin with tunable aggregation-induced stronger magnetism for rapid remediation of plastic fragments. Journal of Hazardous Materials, 2022, 435, 128962. doi: doi.org/10.1016/j.jhazmat.2022.128962
32. Yichuan Zhang, Quan Gao, Weishuo Li, Rongkun He, Liwei Zhu, Qianjin Lian, Liang Wang, Yang Li, Mark Bradley, Jin Geng*. Controlled Intracellular Polymerization for Cancer Treatment. JACS Au, 2022, 2(3), 579-589. doi: doi.org/10.1021/jacsau.1c00373
31. Yang Li*, Pengfei Zhang, Ben Zhong Tang, Diana Boraschi*. Editorial: Immunological Effects of Nano-Imaging Materials. Frontiers in Immunology, 2022, 13,886415. doi: 10.3389/fimmu.2022.886415
2021
30. Diana Boraschi*, Dongjie Li, Yang Li, Paola Italiani. In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials. International Journal of Environmental Research and Public Health, 2021, 18(22), 11769. doi: https://doi.org/10.3390/ijerph182211769
29. Dinoop Ravindran Menon, Yang Li, Takeshi Yamauchi, Douglas Grant Osborne, Prasanna Kumar Vaddi, Michael F Wempe, Zili Zhai, Mayumi Fujita. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses. Pharmaceuticals, 2021, 14(11), 1081. doi: https://doi.org/10.3390/ph14111081
28. Qingle Song, Amaneh Javid, Guofang Zhang, & Yang Li*. Applications of Magnetite-Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives. Frontiers in Immunology, 2021, 12:701485. doi: https://doi.org/10.3389/fimmu.2021.701485
27. Zhenzhen Shi, Yang Li, & Majid Jaberi-Douraki*. Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes. PLoS computational biology, 2021, 17(9), e1009413. doi: https://doi.org/10.1371/journal.pcbi.1009413
26. Ximing Shao, Zhihao Ding, Wenhua Zhou, Yanyan Li, Zhibin Li, Haodong Cui, Xian Lin, Guoli Cao, Binghua Cheng, Haiyan Sun, Meiqing Li, Ke Liu, Danyi Lu, Shengyong Geng, Wenli Shi, Guofang Zhang, Qingle Song, Liang Chen, Guocheng Wang, Wu Su, Lintao Cai, Lijing Fang, David Tai Leong, Yang Li*, XueFeng Yu* & Hongchang Li*, Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. Nature Nanotechnology, 2021, 16(10), 1150-1160. doi: https://doi.org/10.1038/s41565-021-00952-x
25. Giacomo Della Camera, Mariusz Madej, Anna M. Ferretti, Rita L. Spina, Yang Li, Annunziata Corteggio, Tommaso Heinzl, Gergö Sipos, Sabrina Gioria, Alessandro Ponti, Paola Italiani*, Diana Boraschi*, Personalised Profiling of Immune Memory Induced by Nano-imaging Particles in Human Monocytes. Frontiers in Immunology, 2021, 12, 692165. doi: 10.3389/fimmu.2021.692165
24. Qingle Song, Guofang Zhang, Bo Wang, Guoli Cao, Dongjie Li, Yu Wang, Yuqian Zhang, Jin Geng, Hongchang Li, Yang Li*, Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels. ACS Applied Materials and Interfaces, 2021, 13 (31), 36824-36838. doi: https://doi.org/10.1021/acsami.1c08201
23. Guofang Zhang, Yalin Cong, Guoli Cao, Liang Li, Peng Yu, Qingle Song, Ke Liu, Jing Qu, Jing Wang, Wei Xu, Shumin Liao, Yunping Fan, Yufeng Li, Guocheng Wang, Lijing Fang, Yanzhong Chang, Yuliang Zhao, Diana Boraschi, Hongchang Li*, Chunying Chen*, Liming Wang*, Yang Li*, Spike Protein Targeting “Nano-Glue” that Captures and Promotes SARS-CoV-2 Elimination. bioRxiv 2021.04.13.439641. doi: https://doi.org/10.1101/2021.04.13.439641
22. Yuqian Zhang, Guofang Zhang, Guocheng Wang, Lidong Wu, Nancy A Monteiro-Riviere, Yang Li*, The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents. WIREs: Nanomedicine and Nanobiotechnology, 2021, e1717. doi: https://doi.org/10.1002/wnan.1717
21. Lidong Wu, Qiang Cao, Na Liu, Yushi Xiao, Rong Huang, Yang Li*, Hybrid Magnetic Hydrogels Used as Artificial Marine Animals for Noncontact Cleaning, ACS Applied Polymer Materials 3 (2), 2021, 1182-1189. doi: https://doi.org/10.1021/acsapm.1c00019
20. Anna M Ferretti, Sandro Usseglio, Sara Mondini, Carmelo Drago, Rosa La Mattina, Bice Chini, Claudia Verderio, Marianna Leonzino, Cinzia Cagnoli, Pooja Joshi, Diana Boraschi, Paola Italiani, Yang Li, Benjamin J Swartzwelter, Luigi Sironi, Paolo Gelosa, Laura Castiglioni, Uliano Guerrini, Alessandro Ponti*. Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance. Journal of Colloid and Interface Science, 2021, 582, 678-700. doi: https://doi.org/10.1016/j.jcis.2020.08.026
19. Shi Qiu, Jiawen Ji, Wei Sun, Jia Pei, Jian He, Yang Li, Jiao Jiao Li*, Guocheng Wang*, Recent Advances in Surface Manipulation Using Micro-contact Printing for Biomedical Applications, Smart Materials in Medicine, 2021, 2, 65-73. doi: https://doi.org/10.1016/j.smaim.2020.12.002
2020
18. Jing Zhao, Danping Lu, Sergio Moya, Haoying Yan, Miaojuan Qiu, JunZong Chen, Xincheng Wang, Yang Li, Haobo Pan, Guochuang Chen*, Guocheng Wang*. Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system. Applied Materials Today. 2020, 20, 100701. doi: https://doi.org/10.1016/j.apmt.2020.100701
17. Guofang Zhang, Qingle Song, Yuqian Zhang, Ruijing Liang, Liang Chen, Nancy Monteiro-Riviere, Diana Boraschi, Yan-Zhong Chang, Hongchang Li, Yang Li*. Gold Nanoparticles Induce Cell Stress by Interfering with the Cellular Protein Quality Control System. Research Square. doi: https://doi.org/10.21203/rs.3.rs-84361/v1
16. Shu Zhang, Ming Xiao, Yuqian Zhang, Yang Li, Huan Liu, Gang Han, Brijesh Rathi, Kaiyu Lyu, Lidong Wu*. Mimicking neuromelanin nanoparticles as a selective Pb2+ probe. Analytica Chimica Acta, 2020, 105, 208-213. doi: https://doi.org/10.1016/j.aca.2020.01.051
15. Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li, Zhihuan Li, Lilong Lin, Xiaochun Wan, Xiaolu Yang*, Liang Chen*. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Nature communications, 2020, 11 (1), 1-13. doi: https://doi.org/10.1038/s41467-019-14190-2
14. Litian Zhang, Lukman O Afolabi, Xiaochun Wan, Yang Li*, Liang Chen*. Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins. Frontiers in Cell and Developmental Biology, 2020, 8:802. doi: https://doi.org/10.3389/fcell.2020.00802
2019
13. Yuqian Zhang, Guofang Zhang, Liang Chen, Yang Li*. Modulation of the inflammatory tumor microenvironment - a new approach for photothermal-synergized cancer immunotherapy. Nanomedicine, 2019, 14(16), 2101–2104. doi: https://doi.org/10.2217/nnm-2019-0156
2017
12. Yang Li*, Zhenzhen Shi, Isabella Radauer-Preim, Ancuela Andosch, Eudald Casals, Ursula Luetz-Meindl, Jutta Horejs-Hoeck, Martin Himly, Nancy A. Monteiro-Riviere, Victor Puntus, Albert Duschl, Diana Boraschi. Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. Nanotoxicology, 2017, 11(9-10): 1157-1175. doi: https://doi.org/10.1080/17435390.2017.1401142
Before SIAT
11. Dinoop Ravindran Menon, Yuchun Luo, John Arcaroli, Sucai Liu, Lekha KrishnanKutty, Douglas Osborne, Yang Li, Jenny Mae Samson, Stacey Bagby, Aik-Choon Tan, William Robinson, Wells Messersmith, and Mayumi Fujita. CDK1 interacts with Sox2 and promotes tumor initiation in human melanoma. Cancer Research, 2018, 78(23):6561-6574. doi: 10.1158/2F0008-5472.CAN-18-0330
10. Yang Li*, Mayumi Fujita, Diana Boraschi. Endotoxin contamination in nanomaterials leads to the misinterpretation of immunosafety results. Front. Immunol. 2017, 8: 472. doi: https://doi.org/10.3389/fimmu.2017.00472
9. Yang Li, Nancy A. Monteiro-Riviere. Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles. Nanomedicine, 2016. 11(24): 3185-3203. doi: https://doi.org/10.2217/nnm-2016-0303
8. Yang Li*, Paola Italiani, Eudald Casals, Dirk Valkenborg, Inge Mertens, Geert Baggerman, Inge Nelissen, Victor F. Puntes, Diana Boraschi. Assessing the immunosafety of engineered nanoparticles with a novel in vitro model based on human primary monocytes. ACS Appl. Mater. Interfaces. 2016, 8(42): 28437–28447. doi: https://doi.org/10.1021/acsami.6b06278
7. Yang Li*, Diana Boraschi. Endotoxin contamination: a key element for interpretation of nanosafety studies. Nanomedicine, 2016 11(3): 269-287. (2016-2018, most read paper in Nanomedicine) doi: https://doi.org/10.2217/nnm.15.196
6. Yang Li*, Paola Italiani, Eudald Casals, Ngoc Tran, Victor Puntes, Diana Boraschi. Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticles. Nanotoxicology. 2015, 9(4): 462-473. doi: https://doi.org/10.3109/17435390.2014.948090
5. Murali Kumarasamy, Kata Kenesei, Yang Li, Kornél Demeter, Zsuzsanna Környei, Emilia Madarász. Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells. Nanoscale. 2015, 7(9): 4199-4210. doi: https://doi.org/10.1039/C4NR06849A
4. Peng Wang, Xin Nie, Yue Wang, Yang Li, Cuicui Ge, Lili Zhang, Liming Wang, Ru Bai, Zhiyun Chen, Yuliang Zhao, Chunying Chen. Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathway. Small. 2013, 9(22): 3799-3811. doi: https://doi.org/10.1002/smll.201300607
3. Cuicui Ge, Yang Li, Jun-Jie Yin, Ying Liu, Liming Wang, Yuliang Zhao, Chunying Chen*. The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials. NPG Asia Materials. 2012, 4(12): e32. doi: https://doi.org/10.1038/am.2012.60
2. Yang Li, Ying Liu, Yujian Fu, Taotao Wei, Laurent Le Guyader, Ge Gao, Ru-Shi Liu, Yanzhong Chang, Chunying Chen*. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials. 2012, 33(2), 402-411. (ISI web of knowledge-Essential Science Indicators, Highly cited papers). doi: https://doi.org/10.1016/j.biomaterials.2011.09.091
1. Cuicui Ge, Li Meng, Ligeng Xu, Ru Bai, Jiangfeng Du, Lili Zhang, Yang Li, Yanzhong Chang, Yuliang Zhao, Chunying Chen. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. Nanotoxicology. 2012, 6(5), 526-542. doi: https://doi.org/10.3109/17435390.2011.587905
Patents
10. 李洋；李雪金；2022-9-22，中国，202211157048.4
9. 李洋；张国芳；2022-6-30，中国，202210757829.0
8. 李洋；张国芳；2022-6-24，中国，202210725447.X
7. 李洋；张国芳；李冬洁；王雨；李雪金；2022-4-20，中国，202210415210.1
6. 李洋；宋庆乐；张国芳；王博；曹国利；王雨；2021-6-19，中国，202110681016.3
5. 李洋；曹国利；张国芳；宋庆乐；2021-6-12，中国，202110656044X
4. 李洋；王黎明；张国芳；二维纳米材料在抑制冠状病毒的应用，2021-2-22，中国，202110183434X；PCT/CN2021/077226
3. 李洋; 张国芳; 金纳米材料在抑制冠状病毒中的应用, 2021-2-10, 中国, 2021101839019
2. 李洋；张国芳；李红昌；曹国利；宋庆乐；二氧化铈纳米材料在抑制冠状病毒中的应用，2021-2-9，中国，2021101742827
1. 李洋；茶多酚在作为免疫检查点抑制剂及制备用于抗肿瘤的药物中的应用，2019-10-12，中国，201910968758.7；PCT/CN2019/111656
Patent
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